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Reflection AI
Building Frontier
Open Intelligence
REGULUS
Detect. Defeat. Destroy.
Total Autonomous Drone Defeat
EUDIA
The Enterprise Brain
for In-House Legal Teams
Q-CTRL
Pioneering Quantum Infrastructure
Spectro Cloud
The Fast Lane to Production AI
Where we invest.
In a world where everything is AI, we invest from inception to Series A, where domain expertise separates winners from the rest.
AI Infrastructure
The systems powering the AI revolution. From model training and data platforms to the tools enterprises need to deploy AI at scale.
Spectro Cloud
Run AI Infrastructure at Scale
Astronomer
Fully-Managed Airflow Platform
Friendli AI
The Frontier AI Inference Cloud
Vertical AI
Purpose-built AI for the industries where domain expertise matters most: healthcare, legal, financial services, manufacturing, and beyond.
Reify Health
Accelerating Clinical Trials
Eden
AI-Powered Radiology
Smallest AI
Voice AI Infrastructure
Frontier & Deep Tech
Semiconductor design, quantum, defense, and advanced materials — breakthrough science commercialized by founders years ahead of the market.
Revalia Bio
Building the Human Data Stack
QCTRL
Making Quantum Technology Useful
Quintessent
Optical Connectivity Solutions to Scale AI and Compute
Physical Intelligence
AI that operates in the real world — robotics, autonomous systems, and the technologies bringing intelligence to physical environments.
Augmentus
No-Code and Adaptive Robotics Solutions
Regulus
Total Autonomous Drone Defeat
DeepHow
AI-Powered Skilled Trade Training
Enterprise Connectivity
Sierra Ventures has built one of the industry's strongest and longest-running enterprise networks, connecting founders with the leaders building the enterprise. Our CXO Advisory Board, Annual CXO Summit, AI Lab Forum, and EPL Council provide portfolio companies with early access to enterprise buying decision-makers and enterprise leaders, and provide enterprise leaders with early visibility into what's next.
Ali Ghodsi
Founder & CEO, Databricks
CXO Summit Speaker
Thomas Kurian
Google
Chief Executive Officer of Google Cloud
Marc Benioff
Salesforce
Chair, Chief Executive Officer, and Co-Founder
Sandy Venugopal
CIO, Coreweave
CXO Advisory Board
Dave Williams
Chief Information & Digital Officer, Merck CXO Advisory Board
Jason Clinton
CISO, Anthropic
CXO Summit Speaker
Bill McDermott
CEO & Chairman, Service Now
CXO Summit Speaker
Andy Jassy
Amazon
President and Chief Executive Officer
Mike Krieger
Anthropic
CPO
Jeetu Patel
Cisco
President
